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What glyphosate does to your brain

Recently, I wrote about how glyphosate can be linked to the development of autism.
Here, I will try to present the core principles and effects in a little bit more detail. This relates not only to autism, but a lot of modern day diseases.

Neurotransmission

With 100 billion neurons in our brains and 200 firings per second to 1,000 other neurons, we have 20 quadrillion bits of information transmitted per second in our brains. That is a 2 with 16 zeros behind it:

20,000,000,000,000,000 !

Brain cells reach out to each other and form neuronal networks. They also detach themselves from each other and rearrange. This is the concept of neuroplasticity. The brain at any given moment is structurally different than the second before. The main mechanism revolves around the work of neurotransmitters.


Neurotransmitters play a major role in shaping our everyday life and functions. Their exact numbers are unknown, but more than 100 of these chemical messengers have been uniquely identified.

Neurotransmitters serve different functions in the brain. Some are there to run the motor,like glutamate and glycine. Both are needed for the neuron to communicate with other neurons. For example,they help in transmitting information from one brain area to another, e.g. storing an emotion that was just experienced and transfering it via the hippocampus deeply away into the brain cortex.

Most likely you have heard about serotonin, dopamine or oxytocin, but let us focus on only mainly one neurotransmitters: anandamide.

Endocannabinoids

Neurotransmitters belonging to the endocannabinoid family, namely anandamide and 2-AG were discovered in the mid-1990s [hence it is not routinely taught in medical school yet and your local neurologist thinks it’s a bunch of pseudo-science]. Research into these cannabinoid molecules is booming, as they are very much involved into regulating synaptic tone in our entire human organism. If you just search for “cannabinoid” on the national library of medicine, you will find close to 22,000 scientific papers on it. Very real. You produce endocannabinoids as you read this article. Anandamide is highly expressed in 13 different regions of our brain. This molecule is well recognized in its involvement with the neurotransmission processes related to pain, depression, appetite, memory, fertility and cognition. It binds tightly to a receptor called CB1 to execute those actions. Anandamide also binds to CB2 receptors, although much weaker. CB2 receptor activation is done by “the other” endocannabinoid, namely 2-AG, which in the plant world would be represented by CBD.

CB2 receptors are present on immune cells, in the gastrointestinal tract and the peripheral nervous system. The prevalence in the brain is actually very low. It can change, however, when the brain is under attack or coming in contact with toxins,e.g. alcohol. In this case, the brain moves toward upregulation of CB2 receptors. That is because CB2 aids in neuroprotection. In the brain, CB2 receptors are mainly on “pacman-like structures”, which are called microglia.

Microglia

Microglia are a branch of your brain’s armed forces, ready to be deployed at any second. The signal that is required to alert them to start cleaning up toxins or other inflammatory agents is via the CB2 receptor that is on their surface. CB2 receptors can be activated by CBD from the cannabis plant or via your own (endo-)cannabinoids that you produce. The most powerful one we know of is 5,6-EET-EAs.

5,6-EET-EAs – Your brain’s “super-cannabinoid”

This molecule literally acts as “super CBD”, because it activates the CB2 receptor 300 more likely than the CB1 receptor and it activates it 1000 times stronger than CBD would. The way this molecule gets produced is fascinating by itself.

Let’s look at the brain in an inflamed state (as indicated by the red dots = toxic compounds). During inflammation, the brain upregulates the enzyme P450D6 in 13 different brain regions. 
It is a defense mechanism so to say, because what happens next is rather fascinating. P450 activates these microglia “Pacmans” to help with the inflammation. They literally “wake up” and suck up the inflammatory particles like a vacuum. There is some skepticism about microglia. Some say they actually can cause damage. Well, it depends on how you activate these little beasts. For the sake of keeping it easy to grasp, there is a M1 and M2 state in microglia. M1 can be harmful, but M2 signaling is beneficial and currently one of the hottest topics in pharmaceutical research. Of course they don’t want you to know how to turn on microglia into the M2 state. God forbid it comes from a vegetable, one that everyone could grow.

So how can our brains create this super potent “anti-oxidant” 5,6EET-EAs ? Surprisingly, it comes from Anandamide!

There is a shift in the brain towards producing this CB2 activator. When it does so as intended, the inflammation is cleared and processes resume as normal.

In 2013 a study lead by Stephanie Seneff it was elegantly proven how glyphosate causes a disruption in the P450 enzyme in the liver. Understandably, this is concerning, as P450 enzymes elsewhere in the body would be susceptible to a similar fate. We talked about the P450 enzyme in the brain above, and how it converts anandamide into 5,6EET-EAs. You would think that most glyphosate entering the system would not go further than the liver, and that is debatable, sure. But when you inject glyphosate, you bypass the liver and brain access is virtually inevitable. In order to cross the blood-brain barrier, only molecules less than 800-1000 amu (atomic mass unit) in molecular weight can get through. The molecular weight of glyphosate is about 169 amu.

MMR Vaccine vs brain P450

Independent testing done by Mom’s across America and Stephanie Seneff confimed glyphosate levels in ALL childhood vaccinations, with the highest measured concentration in the MMR vaccine.
In 1980, children received 19 shots by age 2, never more than 5 shots a visit. Today, kids receive a staggering 49 doses of 14 vaccines by the age of six. All of them contain glyphosate. 

If you are dealing with an inability to clear the inflammation, you will utilize Anandamide for CB2 purposes, to the expense of CB1. This is why therapy with the whole cannabis plant is called for, as it contains delta-9-thc, the plant’s equivalent to anandamide. As discussed earlier, it is responsible for neurotransmissive functions such as memory formation and cognition, namely attentional mechanisms, associational processes, consolidation processes, encoding processes and retrieval processes.

Wait, is cannabis safe?

According to United States patent #6630507 (filed by the United States department of Health and Human Services) cannabinoids are protecting your brain:

According to the patent, they do so by blocking neuronal activation from excess glutamate and by acting as antioxidants. I claim that this is the mechanism by which cannabinoids are acting as antioxidants and hence offer protection from neuronal cell death.

Summary

There is evidence that aggressive autism behaviors can be explained by chemical imbalances in the body leading to a multitude of health concerns, including chronic neuroinflammation. During this insult, the P450D6 pathway is upregulated, so the very powerful microglial activator 5,6-EET-EAs can be produced from anandamide. One causation hypothesized here is the chemical glyphosate, introduced to the brain via MMR vaccination contamination. This causes an inhibitory effect on P450D6. The consequence is that anti-inflammatory defenses in the brain are limited. Since Anandamide is a CB1 agonist required for neurotransmission in relation to cognition and memory, enough substrate for both CB1 and CB2 receptors should be provided to aid signaling homeostasis . Phyto(=plant)-cannabinoids such as CBD and THC were found to be neuroprotective according to United States Patent #6630507, filed by the Department of Health and Human Services. Microglial activation towards the beneficial M2 state by CBD explains the antioxidant properties mentioned in this plant and are the reason the government keeps cannabis away from you, while big pharma is trying to put the plant in a capsule.

In the next article, I will discuss GcMAF and nagalase, and their involvement in the development of the symptom and/or disease process they call “autism’.

Until then, be careful my friends, the most dangerous part about this vegetable is getting caught with it.

Dr. Christian Bogner

Christian Bogner
 

Dr. Bogner researches plan-based nutrition and the use of cannabis in the treatment of autism and other health conditions.

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